Higuchi connors phase solubility techniques

This was explained by the solubilization theory of Higuchi and Connors. The solubility analysis of the ternary drug/competitor/CyD systems may be particularly useful for determination of the stability constant of a drug whose physicochemical and spectroscopic analyses are difficult, because they can be calculated by monitoring the solubility ...

All the formulations were evaluated at pre and post compression level. Acid solubility profile showed higher solubility in HCl buffer pH2 (296.89±3.49 μg/mL). Mixture of propylene glycol and ...Solubility method (phase solubility analysis) Solubility studies were carried out according to the method reported by Higuchi and Connors (1965) . Excess amounts of DAN were added to aqueous solutions (pH 6.2 ± 0.1) containing increasing concentrations of BCD (2.0 × 10 −3 to 14.0 × 10 −2 M) and the samples were shaken on a rotary shaker ...2.3. Solubility Measurements. Phase-solubility studies of benzoyl metronidazole in aqueous solutions of β-CD were carried out according to the Higuchi-Connors procedure . Various amounts of β-CD were generally dissolved in distilled water, and excess amounts of benzoyl metronidazole were loaded in glass vials. The vials were …Abstract. This current work has been conducted mainly to increase solubility and drug release properties for high hydrophobic Dentatin (DEN) by incorporation it into …Detection of inclusion complexation was done in solution by means of phase solubility analysis, mass spectrometry, and 1 H nuclear magnetic resonance (1 H-NMR) spectroscopic studies, and in solid state using differential scanning calorimetry (DSC), powder x-ray diffractometry (X-RD), scanning electron microscopy (SEM), and in vitro …

K. A. Connors and J. J. Lipari. Effect of cycloamyloses on apparent dissociation constants of carboxylic acids and phenols: Equilibrium analytical selectivity induced by complex formation. J.The results showed an increase in the apparent solubility of ibuprofen in the presence of maltodextrins that depended on their ionization state. The freeze-drying method was used to prepare solid complexes, while physical mixtures were obtained by simple blending.Higuchi, T. and Connors, K. (1965) Phase solubility techniques, in Reilly, C. (ed.), Advances in Analytical Chemistry and Instrumentation, Wiley Interscience, New York, pp. 117–212. Google ScholarSolubility phase diagrams were created to evaluate the molar ratios of GAZ/βCD and GAZ/γCD inclusion complexes and their stability in aqueous solution (Fig. 2).The solubility of GAZ increased linearly with the added concentrations of βCD and γCD and produced an A L solubility phase diagram according to the classification by Higuchi, Connors et al. [12] A-type diagrams are formed when the ...Higuchi, KA Connors. Phase-solubility techniques. Adv Anal Chem Instrum 1965; 4: 117–212. Etodolak’ın Ko-kristalizasyonu: Ko-kristalizasyon Tahmini, Ko-kristal Sentezi, Katı Faz Yapı Aydınlatma Çalışmaları ve In Vitro İlaç Salımı ... Higuchi, KA Connors. Phase-solubility techniques. Adv Anal Chem Instrum 1965; 4: 117–212. Show ...In both cases, concentrations between 0.2% to 20% w/v of CDs in water were used, and the phase solubility studies were carried out according to the method reported by Higuchi and Connors . An excess amount of the berberine chloride was added to the aqueous solutions containing increasing concentrations of RMβCD (1.52 to 152.67 mM) or HPβCD (1 ...The phase solubility curve can be classified as an A L-type diagram, according to the Higuchi and Connors classification (Higuchi and Connors, 1965). The slope of the solubility diagram (0.70) was lower than 1, indicating the formation of 1:1 (mol/mol) ACV-SBE-β-CD inclusion complex.

The apparent stability constant of the KET- BCD complex, assuming 1:1 stoichiometry, were calculated from the slope of the initial straight portion of the phase solubility diagrams as KH = slope/S0(1 - slope) where So is the solubility of the pure drug (Higuchi and Connors, 1965). All the data are the average of three determinations. 2.3.Sep 1, 2010 · HIGHLIGHTS Enhanced curcumin solubility up to 190 fold higher than pure curcumin was investigated The phase solubility results of curcumin range from 5.7×10-4 M-1 and 7.8×10-4 M-1 at 25 and 37 ... Phase-solubility analysis Phase-solubility studies were performed using the method described by Higuchi and Connors [17]. A fixed amount of IDE exceeding its solubility, was added to unbuffered aqueous solutions of SBE-b-CD, (0.0–9.0 9 10-3 M) in 10 mL capped tubes, then sonicated in a Bandelin RK 514 water bath (Berlin, Germany) for 15 …Phase solubility studies. Degree of complexation between nanosponges and SMX has been studied by phase solubility studies as described by Higuchi and Connors . Briefly, an excess amount of SMX (10 mg/ml), and predetermined concentrations of nanosponges in the range of 0-4% (w/v) were added in volumetric flasks in a PBS medium, and placed on a ...

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Phase-solubility studies were performed in triplicate by the method of Higuchi and Connors. ... Phase solubility techniques. Adv Anal Chem Instru 1965;4:17-123 ...Higuchi and Connors, "Phase-Solubility Techniques,", 1964, Box: 11, Folder: 35. Personal papers of Takeru Higuchi, PP 359. University of Kansas. Kenneth Spencer …Phase solubility test was performed according to the method of Higuchi and Connors . An excess amount of camphor was added to aqueous CD (HPβCD and HPγCD) solutions, and the suspensions were shaken at RT. After equilibrium was achieved at the end of 48 h, the suspensions were filtered with 0.45 μm membrane filter.Phase solubility. Compatibility of host and guest relationship was determined by Higuchi-Connors phase solubility method [16]. Excess amount of drug was added in flask containing different molar ratios of βCD mixed in distilled water. Flasks were placed in water bath (TSSWB15-USA) at 37 ± 2 °C with speed of 100 rpm for 72 h.PHASE SOLUBILITY TECHNIQUE IN STUDYING THE FORMATION OF COMPLEX SALTS OF TRIAMTERENE J Pharm Sci. 1964 Nov;53:1325-8. doi: 10.1002/jps.2600531108. Authors L W DITTERT, T HIGUCHI, D R REESE. PMID: 14253586 DOI: 10.1002/jps.2600531108 No abstract available. MeSH terms Chemistry, Pharmaceutical* ...

The CDs complexation of CIM was studied using the phase solubility diagrams method according to Higuchi and Connors. 20 Approximately 60 mg of microcrystalline CIM (A form) was added to 4 mL Britton-Robinson buffer (pH 9.8) ... Phase solubility techniques. Adv Anal Chem Instrum, 4 (1965), pp. 117-212. View in Scopus …Dec 15, 2022 · The solubility of CUR increased linearly with increasing concentrations of β-CD, represented as an A L type phase solubility curve (Higuchi & Connors, 1965; Jiang et al., 2019). The results of ANONA of the phase solubility model were provided in Table 1. F value (409.54) was extremely significant (p value < 0.001) suggesting that the model was ... The present study was aimed to formulate the solid dispersion incorporated microcapsule to improve the dissolution rate and half life of pioglitazone hydrochloride. The solvent evaporation method was used to formulate the solid dispersion resulted increased dissolution rate, bioavailability and stability. Finally increase the half life of the ... The most common and widely used method to evaluate the ability of the inclusion complex is the phase solubility studies by Higuchi and Connors (1965). 23 The plot showed that the drug...In present work, phase solubility analysis were conducted for studying the solubility of terpineol, a natural flavor compound with antifungal and disinfectant …Phase solubility studies in distilled water were conducted according to the method of Higuchi and Connors . Excess amounts of diosmin were added to a series of glass vials containing 10.0 mL of distilled water. ... Higuchi T, Connors KA. Phase solubility techniques. Adv. Anal. Chem. Instrum. 1965; 4:117-212. [Google Scholar] 26. Doile KM ...See Full PDFDownload PDF. Open Access Journal Indian Journal of Medical Research and Pharmaceutical Sciences November 2018;5 (11) ISSN: ISSN: 2349-5340 DOI: 10.5281/zenodo.1490679 Impact Factor: 4.054 PHASE SOLUBILITY ASSESSMENT OF POSACONAZOLE Mohammed Hamed Mohiuddin1 & Shailesh Sharma2 Dept. of Pharmaceutical Sciences, Nims University ...Higuchi T, Connors KA. Phase solubility techniques. Adv Anal Chem Instrum 1965;4:117-212. 10. Asker AF, Whitworth CW. Dissolution of acetyl salicylic acid from acetyl salicylic acid-polyethylene glycol 6000 coprecipitates. Pharmazie 1975;30:530-1. ... T. Higuchi, K.A. Connors. Phase solubility techniques. Adv Anal Chem Instrum, 4 …According to Higuchi and Connors’ theory, [17] the phase-solubility relationships between PD and β- and γ-CDs are classified as typical A L-type, ... according to the method reported by Higuchi and Connors (1965). ... Phase solubility techniques. Adv. Anal. Chem. Instrum., 4 (1965), pp. 117-212. View in Scopus Google ScholarAccording to the Higuchi and Connors classification [6], the phase solubility diagram for the repaglinide – HP- β-CD inclusion complex is A type, which indicates the formation of a soluble complex.

Phase solubility studies of BDQ in the presence of SBE-β-CD was performed according to the method described by Higuchi and Connors [30] and previously ...

Phase Solubility Studies. Phase solubility studies were carried out at room temperature (21 ± 1°C) following the method of Higuchi and Connors . Excess amounts of OME were weighed in glass flasks to which 10 ml of boric/borate buffer pH = 10 were added. These flasks contained increasing amounts of βCD (0–1.5%, w/v) or MβCD (0–5%, w/v).Phase solubility studies. Phase solubility studies were carried out as described by Higuchi & Connors (Higuchi & Connors, 1965). Excess amount of caffeic acid was added to vials containing both CD and ethanol. The concentration of CD varied from 0 to 10 mM and the percentage of ethanol from 0 to 45% v/v.One of the most useful and widely applied analytical approaches in this context is the Phase–solubility method described by Higuchi and Connors [42].... Journal Article • DOI • Cyclodextrins in drug delivery: an updated review.The apparent solubility of the substrates (adenine, guanosine, acyclovir, or triamterene) was appreciably increased by forming complexes with the ligands (vitamins, amino acids, or other ligand). Apparent association constants (K a ) values were measured at 25°C in pH 7 phosphate buffer using phase solubility analysis.Phase-solubility techniques 来自 scienceopen.com 喜欢 0. 阅读量： 717. 作者： TK Higuchi ， A Connors.The most common and widely used method to evaluate the ability of the inclusion complex is the phase solubility studies by Higuchi and Connors (1965). 23 The plot showed that the drug solubility ...Dec 15, 2022 · The solubility of CUR increased linearly with increasing concentrations of β-CD, represented as an A L type phase solubility curve (Higuchi & Connors, 1965; Jiang et al., 2019). The results of ANONA of the phase solubility model were provided in Table 1. F value (409.54) was extremely significant (p value < 0.001) suggesting that the model was ... Phase-solubility profiles and classification of drug/CD complexes according to Higuchi and Connors . Figure 2. In general, one drug molecule (D) forms a complex with one CD molecule in pure water, and, if the complex is water-soluble, an A L -type phase-solubility diagram is observed ( Table 1 ).24 Oca 2006 ... reported by Higuchi and Connors.17 Excess drug (25 mg) was added to 15 mL of ... Phase-solubility techniques. In: Reilly CN, ed. Advances in ...A Way to Increase the Bioaccesibility and Photostability of Roflumilast, a COPD Treatment, by Cyclodextrin Monomers. In vitro digestion showed that CDs protect the drug during digestion and even improve its bioaccessibility, and points to the need to protect roflumilast from light, suggesting that tablets containing the drug might be reformulated.

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T. Higuchi, K. A. Connors, “Phase Solubility Techniques,” Advanced Analytical Chemistry of Instrumentation, Vol. 4, 1965, pp. 117-212. has been cited by the following article: TITLE: Binary and Ternary Complexes of Arteether β-CD - Characterization, Molecular Modeling and in Vivo StudiesSolubility studies. The phase-solubility diagram corresponding to DPS:βCD system is illustrated in Fig. 5. It was performed according to the method reported by of Higuchi and Connors in order to determine the stability constant of the suggested complex and evaluate its stoichiometry. Measurements were made at 291 nm, which corresponds to the ...Types of phase-solubility diagrams according to Higuchi and Connors [11] showing how the total drug solubility changes with increasing CD concentration.Detection of inclusion complexation was done in solution by means of phase solubility analysis, mass spectrometry, and 1 H nuclear magnetic resonance (1 H-NMR) spectroscopic studies, and in solid state using differential scanning calorimetry (DSC), powder x-ray diffractometry (X-RD), scanning electron microscopy (SEM), and in vitro dissolution ...Phase solubility studies The phase solubility studies were carried out according to the method of Higuchi and Connors (Jansook et al. 2018 ; Higuchi & Connors 1965 ). Briefly, an excess of KME was added to 200 μL aqueous solutions of different HP-β-CD concentrations (1, 2, 4, 6, 8, and 10 mM).The Higuchi and Connors 30 method was used to classify the phase-solubility profiles. The apparent stability constant ( K 1:1, eq 1 ) and the CE ( eq 2 ) were determined from the slope of the linear phase-solubility diagrams plots of the total drug solubility ([ D t ]) versus total concentration of CD in liquid phase ([CD liq ]) in moles per ...A phase-solubility study, where the drug (i.e. the substrate) solubility in moles/liter is plotted against the molar CD (i.e. the ligand) concentration, is one of the most common methods applied. Fig. 3 displays the effects CDs can have on drug solubility and the classification of the profiles ( Higuchi and Connors, 1965 ).Types of phase-solubility diagrams according to Higuchi and Connors [11] showing how the total drug solubility changes with increasing CD concentration.(3) (Higuchi and Connors, 1965). As mentioned pre- viously poorly soluble ... Phase-solubility techniques. Adv. Anal. Chem. Instrum. 4, 117–212. Johnson ...The mole fraction solubility of TDL was found to be highest in pure PEG 400 (1.86 × 10- 2 at 298.15 K) as compared to water (5.7 × 10- 7 at 298.15 K). The thermophysical parameters such as enthalpies and entropies for TDL dissolution indicated that the dissolution of TDL is endothermic and an entropy-driven process. ….

Phase solubility studies for Cur/Na 2 GA systems were carried out in aqueous systems at different temperatures to calculate the ... (A L-type relationships), suggesting the formation of 1:1 ‘molecular relations’ of associated complexes/micelles (Higuchi & Connors, Citation 1965). Thus, ... Connors KA. (1965). Phase-solubility techniques. In: Reilley CN, ed. …The two kinds of CDs enhance the aqueous solubility of Res. As shown in Fig. 2, the phase-solubility diagrams of Res with β-CD or HP-CD show a linear relationship between the amount of Res solubilised and the concentration of CDs in solution (A L type diagram). According to the theory of Higuchi and Connors (1965), this may be attributed …[16] T. Higuchi, K. A. Connors, “Phase Solubility Techniques”, Advances in Analytical Chemistry and Instrumentation, 4, 117-150, 1965. [17] T. Higuchi, H. Kristiansen, “Binding specificity between small organic solutes in aqueous solution: Classification of some solutes into two groups according to binding tendencies”, Journal …At 298.2–318.2 K and 101.1 kPa, the solubility of FBX in several mono solvents was measured using an experimental approach proposed by “Higuchi and Connors” . The extra FBX was mixed with the known amount of each mono solvent. The obtained suspensions were vortexed for 10 min.Indeed, the absorption coefficient of THC in the complex depends on ligand concentration within the solution. Solubility diagrams were obtained by plotting THC concentration versus MeβCD concentration. The association constant K is given by the Eq. (1) of Higuchi and Connors (Higuchi and Connors, 1965).The K C and CE were calculated from the intrinsic solubility (S 0 ) in the complexing medium and the initial linear slope of the phase solubility diagram (Higuchi and Connors 1965;Loftsson et al ...The most common and widely used method to evaluate the ability of the inclusion complex is the phase solubility studies by Higuchi and Connors (1965). 23 The plot showed that the drug...ResearchGate | Find and share research Higuchi connors phase solubility techniques, [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1]