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Tofacitinib (Xeljanz, Xeljanz XR ®, US) is an oral small- molecule inhibitor of Janus kinase (JAK) 1 and 3 that is used to treat psoriatic arthritis, rheumatoid arthriti s, inflammatory bowel disease, and ankylosing spondylitis. JAK enzymes respond to extracellular growth factors, and cytokines which activate signal transduction and cell ...

Nz dermnet. DermDiag. The DermDiag Tool is designed to help you understand your skin condition. This tool does not provide medical advice. To get started, select the part of the body where you are experiencing symptoms. We suggest that you search our Glossary if you are unfamiliar with any dermatological terms.

Macular amyloidosis is generally pruritic, although the degree of pruritus varies from mild to severe. It can assume a subtle rippled or reticulated pattern, which resembles the ‘seafloor pattern’ seen in lichen amyloidosis. Macular amyloidosis may co-exist with lichen amyloidosis in up to 25% of affected patients [9].

Urticaria is characterised by very itchy weals (hives), with or without surrounding erythematous flares. The name urticaria is derived from the common European stinging nettle Urtica dioica . Urticaria can be acute or chronic, spontaneous or inducible. A weal (or wheal) is a superficial skin-coloured or pale skin swelling, usually surrounded by ... What is cellulitis? Cellulitis is a common bacterial skin infection of the lower dermis and subcutaneous tissue. It results in a localised area of red, painful, swollen skin, and systemic symptoms. Left untreated, cellulitis can be life-threatening. Similar symptoms are experienced with the more superficial infection, erysipelas, so cellulitis and erysipelas …Chronic spontaneous urticaria is unpredictable and debilitating. The weals are more persistent in chronic spontaneous urticaria than in chronic inducible urticaria, but each tends to resolve or alter in shape within 24 hours.They may occur at certain times of the day. Some patients with chronic spontaneous urticaria report associated systemic …Dyshidrotic eczema (pompholyx) is a chronic, recurrent condition and appears as small, deep-seated, fluid-filled blisters (vesicles) on the sides of the fingers, hands, and feet. The vesicles are small (1–2mm), often symmetrical, with no associated erythema, and they do not occur elsewhere on the body. Vesicles may coalesce into larger blisters.DermNet NZ revision August 2021. Table of contents. Introduction Demographics Causes Clinical features Diagnosis Treatment Outlook. What is pityriasis versicolor? Pityriasis … Basal cell naevus syndrome is a rare genetic cancer syndrome characterised by multiple early onset basal cell carcinomas, odontogenic keratocysts and other tumours, and other abnormalities. Basal cell naevus syndrome (BCNS) is probably best known as Gorlin syndrome, and is also called naevoid basal cell carcinoma syndrome, amongst many other names. The term atypical naevus is sometimes used to mean any funny-looking mole, and sometimes to mean a melanocytic lesion that is suspected of being a melanoma (a cancerous mole). One definition of an atypical naevus is a mole with at least 3 of the following features. Size > 5 mm diameter. Ill-defined or blurred borders.

Photodynamic therapy (PDT) is a treatment used mainly for superficial types of skin cancer. PDT is effective in treating actinic keratoses, in situ squamous cell carcinoma (Bowen disease), and superficial basal cell carcinomas. It may also be used for treatment of small, thin, low-risk nodular basal cell carcinomas outside of the head and neck ... Introduction. Itch is defined by a desire to scratch. An acute or chronic itchy rash is most often due to dermatitis / eczema. Dermatitis can be primary, or secondary to scratching. Stages include: Acute dermatitis: red, oozy, swollen skin. Subacute dermatitis: red, dry skin. Chronic dermatitis: skin coloured or dark, dry, thickened skin with ... DermNet NZ Editor in Chief: Adjunct A/Prof Amanda Oakley, Dermatologist, Hamilton, New Zealand. Copy edited by Gus Mitchell/Maria McGivern. October 2018. Table of contents What are brown spots and freckles? Brown spots and freckles on sun-exposed skin are ephelides (the plural of ephelis) and lentigines (the plural of lentigo). The difference ...The epidermis is the uppermost or epithelial layer of the skin. It acts as a physical barrier, preventing loss of water from the body, and preventing entry of substances and organisms into the body. Its thickness varies according to the body site. The epidermis consists of stratified squamous epithelium. That means it consists of layers of ...Trichotillomania is estimated to affect up to 4% of the general population. It can affect males and females of any age but is more common in children than in adults. Peak of onset usually occurs in the pre-school years and also in early adolescence, usually around the time of puberty. In children, trichotillomania affects boys and girls equally ...What are the features of benign skin lesions? The features in common for benign skin lesions include: Symmetry in shape, colour and structure. Stable or slowly evolving. …

Lichen planus is a chronic inflammatory condition affecting the skin and mucosal surfaces. Learn about its symptoms, causes, diagnosis, treatment, and complications with images …Dermatomyositis is thought to be caused by a microangiopathy affecting skin and muscle. There is a genetic predisposition to the development of dermatomyositis such as the PTPN22 gene and HLA associations identified include: Anti-Mi-2 antibodies: HLA DRB1*07 and DQA*0201. Silica exposure — in tradespeople.This refers to a depression in the skin due to the elastic tissue within the dermis that is lost. Less commonly, acne scarring can result in a keloid or hypertrophic scar. A hypertrophic scar is the same size as the acne lesion that caused it, while a keloid scar is an excessive scar formation often larger than the causative lesion.Tofacitinib (Xeljanz, Xeljanz XR ®, US) is an oral small- molecule inhibitor of Janus kinase (JAK) 1 and 3 that is used to treat psoriatic arthritis, rheumatoid arthriti s, inflammatory bowel disease, and ankylosing spondylitis. JAK enzymes respond to extracellular growth factors, and cytokines which activate signal transduction and cell ...

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Angioedema is caused by an increase in local capillary permeability and plasma extravasation, usually mediated by mast cells, histamine, or bradykinin release. Angioedema is most commonly histamine-mediated; mast cell and basophil stimulation results in histamine release. Angioedema with urticaria tends to suggest a histaminergic …Malignant melanoma may arise from melanocytes found on the skin or rarely from mucosal surfaces, under the nails and in the meninges. Melanoma may arise from common acquired naevi or from dysplastic naevi. They may also arise from the solar lentigo or atypical lentigo. Most arise de novo. The dermoscopic features are enormously variable.Tofacitinib (Xeljanz, Xeljanz XR ®, US) is an oral small- molecule inhibitor of Janus kinase (JAK) 1 and 3 that is used to treat psoriatic arthritis, rheumatoid arthriti s, inflammatory bowel disease, and ankylosing spondylitis. JAK enzymes respond to extracellular growth factors, and cytokines which activate signal transduction and cell ...It feels soft and smooth and is easily moved under the skin with the fingers. It may have a rubbery or doughy consistency. Lipomas are most common on the shoulders, neck, trunk and arms, but they can occur anywhere on the body where fat tissue is present. Most lipomas are symptomless, but some are painful when applying pressure.

A list of the most commonly used key terms and phrases in dermatology. Sun damage ( photoageing, actinic keratoses) Repeated prior episodes of sunburn. Fair skin, blue eyes and blond or red hair — note; BCC can also affect darker skin types. Previous cutaneous injury, thermal burn, disease (eg cutaneous lupus, sebaceous naevus) Inherited syndromes: BCC is a particular problem for families with basal cell naevus ... Guttate psoriasis is a clinical diagnosis, aided by dermoscopy, which can be confirmed on skin biopsy. Examination and investigations should include a search for streptococcal infection. Tests may include: Swabs for bacteriology. Blood tests — Anti-streptolysin O titre (ASOT), anti-DNase B titre. Seborrhoeic keratosis is a harmless warty spot that appears during adult life as a common sign of skin ageing. Some people have hundreds of them. Seborrhoeic keratosis (American spelling - seborrheic keratosis) is also called SK, basal cell papilloma, senile wart, brown wart, wisdom wart, or barnacle. The descriptive term, benign keratosis, is ...Aphthous ulceration is classified into three types. Recurrent minor aphthous ulcer (80%). This is less than 5 mm in diameter and heals within 1–2 weeks. Major aphthous ulcer, which is large (often more than 10 mm) and takes weeks or months to heal and leaves a scar. Herpetiform ulcers, which are multiple pinpoint ulcers that heal within a month.This refers to a depression in the skin due to the elastic tissue within the dermis that is lost. Less commonly, acne scarring can result in a keloid or hypertrophic scar. A hypertrophic scar is the same size as the acne lesion that caused it, while a keloid scar is an excessive scar formation often larger than the causative lesion. Granuloma annulare may be a delayed hypersensitivity reaction to a component of the dermis or a reaction pattern to numerous triggers. Reported triggering events have included many skin infections and infestations, and types of skin trauma. Inflammation is mediated by tumour necrosis factor alpha ( TNF α). The reason this occurs is unknown. Skin conditions caused or aggravated by infection by malassezia include: Pityriasis versicolor – most often due to M. globosa, M. sympodialis and M. furfur. Malassezia folliculitis due to the yeast growing in the hair follicles where they produce inflammation. Steroid acne. Seborrhoeic dermatitis, dandruff, sebopsoriasis and facial or scalp ... Carotenoderma is due to carotenaemia. Primary carotenaemia is usually due to excessive intake of carotenoid-containing foods or supplements. Carotene is found in all pigmented fruits and vegetables. High levels are associated with a deep yellow, orange, or green colour. Examples of fruit and vegetables with a high β-carotene content include ... Welcome to our image library. over 20,000 clinical dermatology images from DermNet. DermNet provides Google Translate, a free machine translation service. Note that this may not provide an exact translation in all languages Macular amyloidosis is generally pruritic, although the degree of pruritus varies from mild to severe. It can assume a subtle rippled or reticulated pattern, which resembles the ‘seafloor pattern’ seen in lichen amyloidosis. Macular amyloidosis may co-exist with lichen amyloidosis in up to 25% of affected patients [9]. Decreased arterial flow. The blockage or narrowing of arteries by the small clots that lead to blue toe syndrome can result from a number of different conditions.. Embolisation. Cholesterol emboli are cholesterol fragments or fibrin – platelet material released into the bloodstream from ulcerated arteriosclerotic plaques in the large arteries (eg, the aorta, …

Alopecia areata is an autoimmune condition affecting hair follicles causing hair loss. It typically presents with discrete bald patches on the scalp but can cause hair loss from all hair-bearing areas on the body. Alopecia is a Latin term meaning hair loss, and areata refers to the patchy nature of the hair loss.

A list of the most commonly used key terms and phrases in dermatology. DermDiag. The DermDiag Tool is designed to help you understand your skin condition. This tool does not provide medical advice. To get started, select the part of the body where you are experiencing symptoms. We suggest that you search our Glossary if you are unfamiliar with any dermatological terms.Molluscum contagiosum is caused by a poxvirus, the molluscum contagiosum virus. There are at least 4 viral subtypes. Sexual transmission in adults. Transmission of molluscum contagiosum appears to be more likely in wet conditions, such as when children bathe or swim together.What is rosacea? Rosacea is a chronic inflammatory skin condition predominantly affecting the central face and most often starts between the age of 30–60 years. Rosacea is … Trichotillomania is estimated to affect up to 4% of the general population. It can affect males and females of any age but is more common in children than in adults. Peak of onset usually occurs in the pre-school years and also in early adolescence, usually around the time of puberty. In children, trichotillomania affects boys and girls equally ... Bimekizumab (Bimzelx®) is a novel humanised immunoglobulin (IgG1) monoclonal antibody used to treat moderate to severe plaque psoriasis, generalised pustular psoriasis, and psoriatic erythroderma. Bimekizumab selectively and directly inhibits interleukin 17A and 17F (IL-17A and IL-17F). It is produced in a genetically engineered … Sun damage ( photoageing, actinic keratoses) Repeated prior episodes of sunburn. Fair skin, blue eyes and blond or red hair — note; BCC can also affect darker skin types. Previous cutaneous injury, thermal burn, disease (eg cutaneous lupus, sebaceous naevus) Inherited syndromes: BCC is a particular problem for families with basal cell naevus ... Tender or asymptomatic. Actinic keratoses are very common on sites repeatedly exposed to the sun, especially the backs of the hands and the face, most often affecting the ears, nose, cheeks, upper lip, vermilion of the lower lip, temples, forehead, and balding scalp. In severely chronically sun-damaged individuals, they may also be found on the ...

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Urticaria pigmentosa. Urticaria pigmentosa is a form of cutaneous mastocytosis in which there are brown macules and papules. Urticaria pigmentosa is mostly seen in infants and improves with age. It may also arise in adults when it tends to persist. Lesions may affect trunk and limbs, and less often scalp and face. Curettage. The lesion should be sent to a pathology laboratory for analysis. The wound surface is then cauterised with a hot wire beaded tip or electrosurgical unit (diathermy). This stops bleeding and helps destroys any remaining skin tumour cells. This procedure is usually repeated twice for malignant skin lesions (serial curettage and cautery).Trachyonychia is characterised by brittle nails that show diffuse longitudinal ridging and can be accompanied by pitting, loss of lustre, or a roughened nail plate. Trachyonychia, also known as ‘rough nails’ or ‘sandpaper nails’, can involve any number of nails. Twenty-nail dystrophy refers to trachyonychia that affects all 20 nails.Skin conditions caused or aggravated by infection by malassezia include: Pityriasis versicolor – most often due to M. globosa, M. sympodialis and M. furfur. Malassezia folliculitis due to the yeast growing in the hair follicles where they produce inflammation. Steroid acne. Seborrhoeic dermatitis, dandruff, sebopsoriasis and facial or scalp ...Bimekizumab (Bimzelx®) is a novel humanised immunoglobulin (IgG1) monoclonal antibody used to treat moderate to severe plaque psoriasis, generalised pustular psoriasis, and psoriatic erythroderma. Bimekizumab selectively and directly inhibits interleukin 17A and 17F (IL-17A and IL-17F). It is produced in a genetically engineered …Author: Qiuyu Jin, Medical Student, University of Auckland, Auckland, New Zealand. DermNet NZ Editor in Chief: Adjunct A/Prof Amanda Oakley, Dermatologist, Hamilton, New Zealand. Copy edited by Gus Mitchell/Maria McGivern. June 2019. DermNet NZ Update July 2021Hereditary haemorrhagic telangiectasia (HHT) is also known as Osler-Rendu-Weber syndrome. It is a rare inherited disorder that affects blood vessels throughout the body and is characterised by a tendency for bleeding ( haemorrhage, American spelling ‘hemorrhage’), in particular recurrent epistaxis (nosebleeds); and skin telangiectasia …Pityriasis rosea is a self-limiting rash that resolves in about 6–10 weeks. It is characterised by a large circular or oval "herald patch" on the chest, abdomen, or back, followed by … ….

Rheumatoid arthritis initially affects the small joints, such as those in the hands, but in later stages can affect any joint. It presents as episodic flares of symmetrical synovitis (swelling, redness, pain of joints), morning stiffness, and enthesitis. Untreated, it progresses to irreversible joint destruction with loss of cartilage and bone. It is characterised by: Open and closed uninflamed comedones (blackheads and whiteheads) Inflamed papules and pustules. In severe acne, nodules and pseudocysts. Post-inflammatory erythematous or pigmented macules and scars. Adverse social and psychological effects. Severity is classified as mild, moderate, or severe. Pityriasis rosea is a self-limiting rash, which resolves in about 6–10 weeks. It is characterised by a large circular or oval "herald patch ", usually found on the chest, abdomen, or back. The herald patch is followed some time later, typically two weeks or so, by the development of smaller scaly oval red patches, resembling a Christmas tree ... A kerion presents as a boggy pus -filled lump, often several centimetres in diameter. It is characterised by marked inflammation. Hairs within the kerion are loose and fall out, often resulting in a bald area ( localised alopecia ). Enlargement of the regional lymph nodes can occur, and some people become systemically unwell with fevers and ... Welcome to our image library. over 20,000 clinical dermatology images from DermNet. DermNet provides Google Translate, a free machine translation service. Note that this …Skin conditions caused or aggravated by infection by malassezia include: Pityriasis versicolor – most often due to M. globosa, M. sympodialis and M. furfur. Malassezia folliculitis due to the yeast growing in the hair follicles where they produce inflammation. Steroid acne. Seborrhoeic dermatitis, dandruff, sebopsoriasis and facial or scalp ...Urticaria pigmentosa. Urticaria pigmentosa is a form of cutaneous mastocytosis in which there are brown macules and papules. Urticaria pigmentosa is mostly seen in infants and improves with age. It may also arise in adults when it tends to persist. Lesions may affect trunk and limbs, and less often scalp and face.DermNet™ is a website that provides reliable information on how to care for skin conditions, by experts in dermatology. You can find pages on various skin diseases, treatments, … With crawling, the extensor aspects of the elbows and wrists, knees and ankles are affected. The distribution becomes flexural with walking, particularly involving the antecubital and popliteal fossae (elbow and knee creases). Dribble and food can cause dermatitis around the mouth and chin. Nz dermnet, [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1]